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X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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DTSTART:20200101T000000
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DTSTART;TZID=Asia/Seoul:20210714T170000
DTEND;TZID=Asia/Seoul:20210714T180000
DTSTAMP:20210420T215116Z
CREATED:20210406T074701Z
LAST-MODIFIED:20210420T215116Z
UID:4368-1626282000-1626285600@www.ibs.re.kr
SUMMARY:Inference for Circadian Pacemaking
DESCRIPTION:This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) \nAbstract: Organisms have evolved an internal biological clock which allows them to temporally regulate and organize their physiological and behavioral responses to cope in an optimal way with the fundamentally periodic nature of the environment. It is now well established that the molecular genetics of such rhythms within the cell consist of interwoven transcriptional-translational feedback loops involving about 15 clock genes\, which generate circa 24-h oscillations in many cellular functions at cell population or whole organism levels. We will present statistical methods and modelling approaches that address newly emerging large circadian data sets\, namely spatio-temporal gene expression in SCN neurons and rest-activity actigraph data obtained from non-invasive e-monitoring\, both of which provide unique opportunities for furthering progress in understanding the synchronicity of circadian pacemaking and address implications for monitoring patients in chronotherapeutic healthcare.
URL:https://www.ibs.re.kr/bimag/event/2021-07-14/
LOCATION:ZOOM ID: 709 120 4849 (ibsbimag)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2021/04/barbel_finkenstadt_rand_crop-e1617768405446.jpg
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20210728T170000
DTEND;TZID=Asia/Seoul:20210728T180000
DTSTAMP:20210717T235315Z
CREATED:20210407T040301Z
LAST-MODIFIED:20210717T235315Z
UID:4383-1627491600-1627495200@www.ibs.re.kr
SUMMARY:Theory and design of molecular integral feedback controllers
DESCRIPTION:This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234)\nAbstract: \nHomeostasis is a recurring theme in biology that ensures that regulated variables robustly adapt to environmental perturbations. This robust perfect adaptation feature is achieved in natural circuits by using integral control\, a negative feedback strategy that performs mathematical integration to achieve structurally robust regulation. Despite its benefits\, the synthetic realization of integral feedback in living cells has remained elusive owing to the complexity of the required biological computations. In this talk I will show that there is a single fundamental biomolecular controller topology that realizes integral feedback and achieves robust perfect adaptation in arbitrary intracellular networks with noisy dynamics. This adaptation property is guaranteed both for the population-average and for the time-average of single cells. On the basis of this concept\, I will describe a genetically engineered synthetic integral feedback controller in living cells and demonstrate its tunability and adaptation properties. A growth-rate control application in Escherichia coli shows the intrinsic capacity of our integral controller to deliver robustness and highlights its potential use as a versatile controller for regulation of biological variables in uncertain networks. These results provide conceptual and practical tools in the area of cybergenetics\, for engineering synthetic controllers that steer the dynamics of living systems.
URL:https://www.ibs.re.kr/bimag/event/2021-07-28/
LOCATION:ZOOM ID: 709 120 4849 (ibsbimag)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2021/04/MustafaKhammash_profile-e1617768310550.jpg
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
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