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PRODID:-//Biomedical Mathematics Group - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Asia/Seoul
BEGIN:STANDARD
TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20220101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20230705T120000
DTEND;TZID=Asia/Seoul:20230705T130000
DTSTAMP:20260426T013323
CREATED:20230629T055533Z
LAST-MODIFIED:20230704T011831Z
UID:7964-1688558400-1688562000@www.ibs.re.kr
SUMMARY:Hyukpyo Hong and Seokmin Ha
DESCRIPTION:Hyukpyo Hong: Advancing Infectious Disease Modeling: Estimating Reproduction Number with Realistic Latent and Infectious Periods \nSeokmin Ha: Systematic inference-driven experiments reveal a fundamental mechanism governing clock protein interactions in plants
URL:https://www.ibs.re.kr/bimag/event/2023-07-05-lls/
LOCATION:Tea Room\, IBS\, Daejeon\, Daejeon\, 34141\, Korea\, Republic of
CATEGORIES:Lunch Lab Meeting Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20230707T140000
DTEND;TZID=Asia/Seoul:20230707T160000
DTSTAMP:20260426T013323
CREATED:20230529T032440Z
LAST-MODIFIED:20230707T034944Z
UID:7807-1688738400-1688745600@www.ibs.re.kr
SUMMARY:Hyun Kim\, scPrisma infers\, filters and enhances topological signals in single-cell data using spectral template matching
DESCRIPTION:We will discuss about “scPrisma infers\, filters and enhances topological signals in single-cell data using spectral template matching”\, Karin\, Jonathan\, Yonathan Bornfeld\, and Mor Nitzan.\, Nature Biotechnology (2023): 1-10. \nAbstract \n\n\n\nSingle-cell RNA sequencing has been instrumental in uncovering cellular spatiotemporal context. This task is challenging as cells simultaneously encode multiple\, potentially cross-interfering\, biological signals. Here we propose scPrisma\, a spectral computational method that uses topological priors to decouple\, enhance and filter different classes of biological processes in single-cell data\, such as periodic and linear signals. We apply scPrisma to the analysis of the cell cycle in HeLa cells\, circadian rhythm and spatial zonation in liver lobules\, diurnal cycle in Chlamydomonas and circadian rhythm in the suprachiasmatic nucleus in the brain. scPrisma can be used to distinguish mixed cellular populations by specific characteristics such as cell type and uncover regulatory networks and cell–cell interactions specific to predefined biological signals\, such as the circadian rhythm. We show scPrisma’s flexibility in incorporating prior knowledge\, inference of topologically informative genes and generalization to additional diverse templates and systems. scPrisma can be used as a stand-alone workflow for signal analysis and as a prior step for downstream single-cell analysis.
URL:https://www.ibs.re.kr/bimag/event/2023-07-07-jc/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20230728T100000
DTEND;TZID=Asia/Seoul:20230728T110000
DTSTAMP:20260426T013323
CREATED:20230619T074840Z
LAST-MODIFIED:20230726T042649Z
UID:7948-1690538400-1690542000@www.ibs.re.kr
SUMMARY:Yun Min Song\, The singularity response reveals entrainment properties of the plant circadian clock
DESCRIPTION:We will discuss about “The singularity response reveals entrainment properties of the plant circadian clock”\, Masuda\, Kosaku\, et al.\, Nature Communications 12.1 (2021): 864. \nAbstract \n\n\n\n\n\n\nCircadian clocks allow organisms to synchronize their physiological processes to diurnal variations. A phase response curve allows researchers to understand clock entrainment by revealing how signals adjust clock genes differently according to the phase in which they are applied. Comprehensively investigating these curves is difficult\, however\, because of the cost of measuring them experimentally. Here we demonstrate that fundamental properties of the curve are recoverable from the singularity response\, which is easily measured by applying a single stimulus to a cellular network in a desynchronized state (i.e. singularity). We show that the singularity response of Arabidopsis to light/dark and temperature stimuli depends on the properties of the phase response curve for these stimuli. The measured singularity responses not only allow the curves to be precisely reconstructed but also reveal organ-specific properties of the plant circadian clock. The method is not only simple and accurate\, but also general and applicable to other coupled oscillator systems as long as the oscillators can be desynchronized. This simplified method may allow the entrainment properties of the circadian clock of both plants and other species in nature.
URL:https://www.ibs.re.kr/bimag/event/2023-07-28/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20230731T120000
DTEND;TZID=Asia/Seoul:20230731T130000
DTSTAMP:20260426T013323
CREATED:20230629T055843Z
LAST-MODIFIED:20230731T143536Z
UID:7966-1690804800-1690808400@www.ibs.re.kr
SUMMARY:Yun Min Song and Seokjoo Chae
DESCRIPTION:Yun Min Song: Noisy delay denoises biochemical oscillators \nSeokjoo Chae: Reduction of spatiotemporal model and its validity condition
URL:https://www.ibs.re.kr/bimag/event/2023-07-31-lls/
LOCATION:Tea Room\, IBS\, Daejeon\, Daejeon\, 34141\, Korea\, Republic of
CATEGORIES:Lunch Lab Meeting Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
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