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X-WR-CALNAME:Biomedical Mathematics Group
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
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DTSTART:20250101T000000
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DTSTART;TZID=Asia/Seoul:20260814T100000
DTEND;TZID=Asia/Seoul:20260814T120000
DTSTAMP:20260730T035435Z
CREATED:20260730T035435Z
LAST-MODIFIED:20260730T035435Z
UID:12774-1786701600-1786708800@www.ibs.re.kr
SUMMARY:Evolution of error correction through a need for speed - Kangmin Lee
DESCRIPTION:In this talk\, we discuss the paper “Evolution of error correction through a need for speed” by Riccardo Ravasio et al.\, Science\, 2026. \nAbstract: \nKinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication\, transcription\, and translation. Proofreading is typically assumed to evolve when selection for fidelity outweighs costs in energy and the speed of replication. We show that when stalling after misincorporations is accounted for\, proofreading can instead speed up replication. Consistent with data on polymerase mutagenesis\, our results suggest that proofreading can evolve under selection for speed alone. We generalize to multicomponent self-assembly and show that analogous error-correcting processes\, such as dynamic instability\, can likewise emerge purely from selection for rapid assembly. Thus\, nonequilibrium error correction can evolve from selection for speed\, even without direct fidelity advantages. We discuss implications for mutation-rate evolution\, molecular assembly processes\, and models of early life.
URL:https://www.ibs.re.kr/bimag/event/evolution-of-error-correction-through-a-need-for-speed-kangmin-lee/
LOCATION:108\, Conference Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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