면역질환 정복 꿈꾼다
경상북도 포항시 남구 청암로 77 (지곡동)
POSTECH 생명공학연구센터 286호
IBS 면역 미생물 공생 연구단
연구단장 찰스 서(1961~2017)
면역학 분야의 세계적 권위자로 미국 스크립스 연구소에서 근무하였다. 2008년에는 포유류 내 질병 치료물질의 생물학적 활성 증가 방법에 대한 국제특허를 취득하였다.
2011년 T세포 항상성 관련연구를 네이처 지에 게재한 바 있다.
면역 체계와 공생 세균간의 항상성 조절 기작 규명 및 연구
The immune system is essential to protect the host from invasion by pathogenic microbes and outgrowth of cancerous host cells. It is both powerful and versatile, capable of mobilizing a customized potent response to the vast array of pathogens and tumors. Because of its strength, the activated immune response is tightly regulated and is, upon elimination of the invaders, rapidly extinguished to prevent collateral tissue damage. The immune system thereafter “remembers”the invaders and is capable of mounting a stronger and quicker response to subsequent invasions by the same pathogen or cancer.Effective immunity requires a complex network of interactions between multiple types of cells. The primary lymphoid tissues generate immune cells, whose activation is initiated in the secondary lymphoid tissues.
Immune cells are also distributed throughout the non-lymphoid tissues and are particularly prominent in the mucosal tissues that are exposed to the environment. Here, these immune cells perform a highly specialized function by providing protection from environmental pathogens while maintaining operational tolerance to benign antigens and to the massive numbers of commensal microbes that co-exist peacefully with the host. While many key mechanisms that regulate the immune system have been deciphered, much more remain yet to be discovered. The goal of AIM is to discover several of these unknown fundamental mechanisms. Particular focus will be placed on elucidating the mechanisms by which various populations of lymphocytes develop and function, how these cells are activated and regulated in order to protect the host without causing collateral tissue damage, and how these cells co-exist peacefully with the commensal microbes while conferring protective immunity against pathogenic microbes. These discoveries should lead reveal novel approaches to enhance immunity against pathogens and cancer and to prevent or ameliorate chronic immune inflammatory disease, such as autoimmunity, allergies, atherosclerosis and metabolic diseases.
면역미생물 공생 연구단은 연구단장(Charles D. Suth) 아래 3개의 연구그룹이 있고, 임신혁 부연구단장 밑에 2개의 연구그룹이 있습니다. Charles D. Suth 단장아래에는 T-cell Biology Lab, Gastro intestinal Immunology Lab, T-cell Homeostasis Lab이 있습니다. 임신혁 그룹리더 아래에는 Immune Regulation and Tolerance Lab, T-reg Cell Lab이 있습니다.
연구단은 자문위원회(SAB)와 관리팀이 있으며 거점시설로는 실험 동물시설(무균/무항원 마우스 시설)과 Flow & Imaging Facillity 가 있습니다.
2017년 3월 기준